Death

Player Effects Attributes Flight Temporary Buffs Death This article is about the conditions that will kill Isaac. For the Death tarot card, see Cards and Runes. For the boss, see Death (Boss). Death occurs when Isaac runs out of health. There are multiple ways to cause this. • Damage from monsters • Damage from bosses • Damage from obstacles • Damage from bombs • Damage from a Blood Donation Machine • Damage from Curse Rooms • Trading your last bit of health when making a deal with the Devil unless that item provides any hearts in return, such as the Ceremonial Robes • Using The Bible against Satan • Using the Suicide King card • ... and more. As long as Isaac has health of any type (Red, Black, Soul, Bone, Rotten, or Coin hearts) left, they will not be killed, except if Isaac only has an Eternal Heart, though this is impossible. • The Lost - It's complicated Die in a Sacrifice Room while holding Missing Poster. • Lil Spewer - Have Isaac die to his own explosion from Ipecac, Bob's Rotten Head, or a Horf! pill.