失忆症#25

Pickups Hearts Coins Bombs Keys Batteries Pills Cards/Runes Chests Sacks Pills are pickups that can provide useful or inhibiting effects. They take up the same slot as cards and runes. At the start of each run, an effect is randomly assigned to each color of pill. The pill effect for each color will remain constant throughout the run. (However, it is possible for PHD, Virgo, False PHD, or Lucky Foot to reassign some of the effects, such that 2 different colored pills will have the same effect.) Pills start the game unidentified (unless the player is holding PHD or False PHD); their effect is shown as "???" when picked up. Upon using a particular pill for the first time, its effect will be revealed and all subsequent pills with the same color will have their effect shown as well. The set of pill effects for any given run is usually known as the pill pool.

• The pill pool for each run has increased from 9 to 13.
• Marbles - Use 5 Gulp! pills in one run (Placebo uses count).
• Lachryphagy - Collect 10 "Tears Up" items or pills in one run.
• Lil Spewer - Have Isaac die to his own explosion from Ipecac, Bob's Rotten Head, or a Horf! pill.

• The Vurp! pill is a portmanteau of the words vomit and burp.
• Power Pills activating the Gamekid effect is a reference to Pac-Man, in which the "Super-Pac" powerup is obtained by eating a Power Pellet.
• "I Found Pills (and Ate Them)," "R U a Wizard?," and "I can see Forever" are all image macro memes.
• The Feels like I'm walking on sunshine! pill is a reference to a quote from the show "Intervention", where someone addicted to huffing computer duster says it feels like "walking on sunshine" (Said by Edmund McMillen in a TikTok video)
• Balls of Steel is a reference to Duke Nukem; it is one of Duke's more famous quotes.
• Explosive Diarrhea is extremely loud and forceful diarrhea. In the original game, the message that displayed when the pill was activated was "Oh No!". The pill name and effect are likely a reference to Atomic Bomberman where a pickup of the same name would cause the player to drop bombs behind them uncontrollably for a short duration.
• Shot speed effects were introduced in The Binding of Isaac: Eternal Edition, after the release of Rebirth. They were finally added to Rebirth in the Repentance DLC.
• Hematemesis is a medical term for vomiting blood.
• Lemon Party is a reference to internet shock site featuring a group of elderly men performing oral sex, peeing on each other.
• "Puberty" having a negative sound effect is a tongue in cheek connotation to how unpleasant that period in life can be.
• Friends Till the End! was originally in the Wrath of the Lamb but removed in Rebirth, then put back into Afterbirth.
• Friends Till The End! is the only non-narrated pill.
• 48 Hour Energy is a reference to the drink 5 Hour Energy.
• X-Lax is a reference to the anti-constipation medicine Ex-Lax.
• "One makes you larger" and "One makes you small" are references to Alice in Wonderland, and the specific wording is a reference to the song White Rabbit by Jefferson Airplane.
• "Percs" is a reference to a street name for the prescription drug Percocet, which is more generically known as Oxycodone. This drug is meant to be used to treat pain, but it is often abused for recreational purposes.
• The "???" is the only pill that has 3 different narrated voice lines.
• "Horse pills" is a slang term used to refer to large, hard to swallow pills, hence their sprites being larger than those of regular pills.

Bug! Any blue flies and blue spiders created by pill effects can be multiplied when Glowing Hourglass teleports Isaac in a way that does not move him to a different room from the one he is currently in (such as by teleporting to the previous room then using it again). Tainted Cain Unlocks Tainted Eve Unlocks Mega Satan Unlocks The Binding of Isaac: Rebirth

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